Bioaccessibility and Intestinal Transport of Deltamethrin in Pacific Oyster (Magallana Gigas) Using Simulated Digestion/NCM460 Cell Models.

Yadan Jiao,Hui Hong,Yuqing Tan,Yongkang Luo,Chune Liu,Joe M Regenstein,Chunsong Feng

doi:10.3389/fnut.2021.726620

Abstract

Deltamethrin (DEL) can be introduced into the food chain through bioaccumulation in Pacific oysters, and then potentially threaten human health. The objective of this study was to investigate the bioaccessibility of DEL in oysters with different cooking methods after simulated digestion. DEL content in different tissues of oysters going from high to low were gills, mantle, viscera, and adductor muscle. Bioaccessibility of DEL in oysters decreased after steaming (65%) or roasting (51%) treatments compared with raw oysters (82%), which indicated that roasting can be used as a recommended cooking method for oysters. In the simulated digestion process, the concentration of DEL in the digestive juice and the bioaccessibility of DEL were affected by the pH in the gastric phase. And the transport efficiency of DEL through the monolayer molecular membrane of NCM460 cells ranged from 35 to 45%. These results can help assess the potential harm to consumers of DEL in shellfish. Furthermore, it provides a reference for the impact of lipophilic toxins in seafood.

Highlights

Synthetic pyrethroids are broad-spectrum, efficient, and neurotoxic pesticides
The pH of gastric phase will affect the bioaccessibility of deltamethrin in oysters
Previous studies have reported that pyrethroids were more toxic to Bioaccessibility of Deltamethrin in Oysters aquatic animals than to mammals because of their lower ability to degrade pyrethroid pesticides [4, 5]

Summary

Introduction

Synthetic pyrethroids are broad-spectrum, efficient, and neurotoxic pesticides. Pyrethroid use markedly increased and became the preferred choice in many agriculture-based countries in the last two decades since the implementation of restrictions on the sale of organophosphorus insecticides [1, 2]. Pyrethroids have high insecticidal potency but they have a low toxicity with birds and mammals [3]. Previous studies have reported that pyrethroids were more toxic to Bioaccessibility of Deltamethrin in Oysters aquatic animals than to mammals because of their lower ability to degrade pyrethroid pesticides [4, 5]. Pyrethroids are generally not directly used in aquaculture. There are some reports of pyrethroid pesticide residues in aquatic products and their habitat [6,7,8]

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Conclusion