Bio-O1-07 - miRNA signature in early-stage mycosis fungoides

Abstract

<h3>Background:</h3> Altered miRNA expressions are assigned pathogenic properties in several cancers including mycosis fungoides (MF) and could play a role in the early onset of the disease. <h3>Objective:</h3> To examine disease specific miRNA expression in early-stage MF patch and plaque lesions. <h3>Methods:</h3> We used a qRT-PCR platform of 384 human miRNAs to study the miRNA expression in 154 diagnostic MF biopsies. <h3>Results:</h3> One-hundred-and-ten miRNAs were significantly differentially expressed (>2-fold, P<0.05) between plaque lesions and healthy controls, and 90 miRNAs (>2-fold, P<0.05) differed between patch lesions and healthy controls. Moreover, 13 miRNAs differed in expression between patch and plaque lesions. Early-stage MF exhibited miRNA features overlapping with psoriasis. However, 39 miRNAs, including miR-142-3p, miR-150 and miR-146b, were MF specific. <h3>Conclusion:</h3> Early-stage MF express a distinct miRNA profile indicating that miRNAs play a role in the early development of MF.