Abstract
Atomic force microscopy has recently been used to measure the binding force between two biomolecules; complementing the experiments are computational molecular dynamics studies that seek to reveal the details of the binding and unbinding mechanisms. In his Perspective, Berendsen discusses the results reported in the same issue by Grubmüller et al. ( p. 997 ) on numerical simulations of the binding and separation of biotin from streptavidin, which show excellent agreement with measurements of the rupture force. [Data] (0.9 Mbytes) A global view of the rupture process. (European Readers can visit the Grubmüller et al. Home Page ) [Data] (1.5 Mbytes) A detailed view of the binding pocket. (European Readers can visit the Grubmüller et al. Home Page )
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