Bio-Molecular Allele Frequencies Availability of 23Y-Str Markers Polymorphisms and Odontogenic Diseases in Iraqi Population Study

Abstract

Orofacial diseases of multidiscipline nature from carious lesions to tumors are significant diseases attacka large number of individuals around the world. However, In the recent years, bioinformatics methodshave been reported to analyses several loci of simultaneously. Moreover, Analysis of molecular variance(AMOVA) (23) was performed to measure the geneticdistance between the Iraqi populationsample andreference data from populations. In this study, we analyzed the genetic polymorphisms of 23 Y-STR locifrom PowerPlex® Y23 system in 313 unrelated healthy male individuals from Iraqi populations, andobserved 283 different haplotypes including 269 unique haplotypes and 16 duplicate haplotypes. in which283 different haplotypes was identified classified into 264 (93, 23%) as a unique Haplotype and 19 (6,77%) as replicated haplotype among individuals. The highest haplotype were found in sample H45, H85,H135,H213 and H241 at frequency 0.010 ( haplotype replicated 3 times ), While 264 haplotype with 0.0033frequency and haplotype diversity was 0.996 with a discrimination capacity 0.93 respectively. The genediversity values ranged from 0.3942 at DYS438 to 0.9607 at DYS385a/b. Such results indicated that the 23Y-STR loci were highly polymorphic in Bagdad population and played crucial roles in forensic applicationas well as population genetics. For the first time, we reported the genetic diversity of male lineages inBagdad population at a high-resolution level of 23 Y-STR set and consequently contributed to familialsearching, Odontologic science application tracking, and anthropology analysis of Bagdad population.