Abstract
Biosynthesized low dimensional (<10 nm) nanoparticles are gaining great attention in biomedical applications. Present research emphasizes a comparative study of silver nanoparticles (Ag NPs) and Ag NPs decorated with reduced graphene oxide nanocomposites (Ag NPs@rGO) synthesized from chemical and green methods, and appraisal of their bioactivities and toxicity. We have used a unique sida acuta leaf extract containing a multiplex combination of assorted bioactive compounds, as a reducing agent of NPs formation from metal ions. We controlled the synthesis conditions of molar ratio, pH, and reaction time to obtain performance enhanced Ag NPs. Extremely-tiny spherical shaped Ag NPs (5 nm) with quite a delicate particle dispersion over mono-layer graphene nanosheets was observed in green mediated Ag NPs@rGO.The green synthesized Ag NPs@rGO outperformed to chemically prepared Ag NPs and their composites for 500 μg/mL opposed to Methicillin-resistant Staphylococcus aureus (MRSA) and Proteus mirabili bacteria. The G-Ag NPs and G-Ag NPs@rGO demonstrated the highest cytotoxicity rate against MCF-7 cells at the half-maximal inhibitory concentration (IC50) of 100 μg/mL and 108 μg/mL. Moreover, the green mediated Ag NPs showed 99.18% anti-inflammatory, 96.09% anti-diabetic and 75.68% antioxidant activities at 500 μg/mL according to their excellent temperature stability. Ultimately, this study probes the novel approach of plant-mediated NPs overcruel chemically incorporated NPs applied in pharmaceutical applications.
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