Abstract
In vitro technology facilitates the replication of in vivo tissues more accurately than conventional cell-based artificial organs, enabling researchers to mimic both the structural and functional characteristics of natural systems. Here, we demonstrate a novel spiral-shaped self-pumping microfluidic device for the cleaning of urea by incorporating reduced graphene oxide (rGO) modified a Polyethersulfone (PES) nanohybrid membrane for efficient filtration capacity. The spiral-shaped microfluidic chip is a two-layer configuration of polymethyl methacrylate (PMMA) integrated with the modified filtration membrane. In essence, the device replicates the main features of the kidney (Glomerulus), i.e., a nano-porous membrane modified with reduced graphene oxide to separate the sample fluid from the upper layer and collect the biomolecule-free fluid through the bottom of the device. We have achieved a cleaning efficiency of 97.94 ± 0.6 % using this spiral shaped microfluidic system. The spiral-shaped microfluidic device integrated with nanohybrid membrane has potential for organ-on-a-chips applications.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Biological Macromolecules
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
