Abstract
Bio-inspired design approaches to artificial blood technology: Oxygen carriers Allan Doctor, MD, Professor of Pediatrics at the University of Maryland School of Medicine, shares his expertise on bio-inspired design approaches to artificial blood technology: oxygen carriers. There is a need for an artificial oxygen (O2) carrier for use when banked blood is unavailable or undesirable. To date, efforts to develop Hb-based oxygen carriers (HBOCs) have failed successful translation, because of design flaws that do not preserve physiologic interactions of normal red blood cells (RBCs): First, HBOCs capture O2 in lungs but do not release O2 effectively to tissue, and second, HBOCs trap nitric oxide (NO), causing vasoconstriction – which critically limits blood flow, particularly in ischemic vascular beds; together, failure to both effectively release (to tissue) captured O2 and blood flow restriction undermines the potential benefit from otherwise improved O2 content.
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