Abstract
This proposed paper demonstrates the development of a bio-functionalized tapered multimode optical fiber for the detection of anti-Dengue virus NS1 Immunoglobin G (IgG). The tapered fiber with waist diameter and waist length of 10 $\mu \text{m}$ and 10 mm, respectively, promotes the penetration of light modes to the core-cladding interface, creating evanescent wave that are sensitive to changes on the fiber surface. As the fiber is bio-functionalized with Dengue virus (DENV) NS1 glycoprotein specific to anti-DENV NS1 IgG antibodies, alteration on the surface is selective towards the presence of IgG antibodies. The absorbance-based sensor obtained a sensitivity value of $7 \times 10$ −6 a.u/pg/mL with a detection time under 2 min. This paper shows great potential for real-world deployment which impact may bring Dengue diagnostics a step further.
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