Bio-fabrication of multifunctional nano-ceria mediated from Pouteria campechiana for biomedical and sensing applications

Abstract

The present study focuses on the synthesis of size-controlled nano-ceria (CePC NPs) from aqueous extract of Pouteria campechiana via self-propagating solution combustion synthesis. The extract volume is varied to know the influence of extract on the physical, optical and surface properties of CePC NPs. The p-XRD study revealed the size-controlled synthesis of CePC NPs from 11.46 to 15.59 nm. The nano-regime size is having a definite effect on the biomedical and sensing applications of the NPs. The specific surface area of 34.04 m2g−1, with a maximum pore diameter of 24.33 nm was observed for CePC NPs with a size 11.46 nm. The antioxidant behaviour was maximum with 71.73% of DPPH inhibition at concentration 500 μg/mL. In vitro A546 cancer suppressive activity of CePC NPs reveals that phytochemicals functionalized by highest volume during synthesis showed a low IC50 value of 118.92 μg/mL despite the large size. The bio-derived NPs shows RBC membrane protection above ∼93%, owing to its non-toxic behaviour. The CePC NPs exhibits suitable antibacterial applications against Bacillus subtilis, Staphylococcus aureus, Pseudomonas syringae and Pseudomonas aeruginosa. The bio-fabricated samples exhibited the best hydrogen diffusion value of 1.035 × 10−5. The Rct values of the CePC NPs are comparable with each other (∼73.03–90.39 Ω) with high capacitance, and hence the bio electrodes have superlative efficiency in sensing the Paracetamol drug.