Abstract
Galactomannan (PSP001) isolated from the fruit rind of Punica granatum was employed to fabricate spherical silver nanoparticles (SNP@PSP) by engaging the principles of green chemistry. This bio-fabrication approach was well-translated with improved biocompatibility. However, SNP@PSP was capable of inducing cytotoxicity in cancer cells. The mechanistic investigation into the aspects of cell death indicated major hallmarks of apoptosis. The study also provides scientific evidence that SNP@PSP mediates apoptosis by upregulating the expression of Bax, cleaved Caspase 3, and cleaved PARP. The translational potential of these biogenic nanoparticles was studied in murine cancer models. The absence of any major toxicity symptoms and clear signs of immune-stimulatory features were observed. Comprehensive investigation in Ehrlich ascites carcinoma (EAC) solid-tumor syngeneic mouse models proved that SNP@PSP can significantly reduce solid tumor burden, and increase median survival and life span. Moreover, SNP@PSP is efficient as a chemo-preventive agent, with the best overall response when administered before tumor induction.
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