Bio Evaluation of Mirabilis Jalapa Leaves Extract for Anxiolytic Activity in Animal Model

Abstract

Anxiety is an exaggerated feeling of apprehension, uncertainty and fear. It is an unpleasant state of tension with an anticipation of imminent danger. It may be regarded as a particular form of behavioral inhibition that occurs in response to environmental events that are Novel. In recent times, there are many indigenous plants have beneficial properties to treat mental disease and psychic complaints. Mirabilis Jalapa Linn (family- Nyctanginaceae) is one of the plants that used for health care and medicinal purpose for thousands of years. It has traditionally been used in the treatment of gastrointestinal disorders, muscle pain, abdominal colic, and diarrhea. However, studies have evidenced its antibacterial, antiviral, antioxidant, anti-diabetic, anti-inflammatory, anti-stress and many other activities. The purpose of this study was to prepare & evaluate Methanolic extract of leaves of mirabilis Jalapa for the treatment of anxiety in animal models. The dried leaves were extracted with methanol separately and administered the dose of 200mg/kg and employed in elevated plus maze test and open field test with 2mg/kg i.p.of Diazepam as a standard drug to assess the anxiolytic activity. The result reveled that methanol leaf extract was more impetus due to high amount of flavonoid, phenolic compound, steroids; terpenoid contents possess tremendous anti-anxiety activity. This study suggested that the M.Jalapa is much more active compound consistent medicinal plant to derive a potent drug against Anxiety