Bio-conjugated N-(2-hydroxy-1-naphthaldehyde)-glucosamine Cu(II) complex: Bacterial sensitivity and superoxide dismutase-like activity

Abstract

Bacterial sensitivity and super-oxide dismutase (SOD) activity of sugar Schiff base complexes represent great fascinating areas of research. Under such curiosity, herein a new glucosamine Schiff base Cu(II) complex of N-(2-hydroxy-1-naphthaldehyde)-glucosamine is reported. The compound has been characterized on the basis of various physicochemical techniques in association with density functional theory (DFT) approach. Becke-3-Lee-Yang-Parr (B3LYP)/Los Alamos National Laboratory 2 Double Z (LanL2DZ) specified of Cu atom and 6311G/B3LYP for all other atoms were applied for the theoretical analysis. From the study, experimental observations and theoretical outcomes have been found in close agreement with one another. A suitable square planar geometry has been suggested for the complex. Moreover, the Schiff base ligand and its metal complex were screened for the broad spectrum antibacterial sensitivity and SOD activity. Streptococcus pyogenes, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Salmonella typhus were the bacterial strains selected for the antimicrobial tests. From the measurement of inhibition zones, it is clear that the model compound is not so much bactericidal against the selected microbes. However, due to well-pronounced results obtained under SOD assay, the complex could be suggested for in vivo practice for detoxification of superoxide species.