Abstract
Polyethylene (PE) was implanted with 15 keV Ar + and Kr + ions to the fluences from 3 × 10 12–1 × 10 15 cm −2 and subsequently grafted with amino acid sequence Arg–Gly–Asp (RGD), i.e. a minimum adhesion motif recognized by integrin receptors on cells. The structural changes of PE were studied using goniometric technique, UV–VIS, LIF spectroscopy and by measuring specimen electrical resistance. The adhesion and proliferation of mouse embryonic fibroblasts 3T3 on the modified PE were studied under in vitro conditions. Addition of RGD sequence onto double bonds created by the ion irradiation on polymeric chain was observed. The adhesion and proliferation of the 3T3 cells is increased by ion implantation and additionally also by RGD grafting.
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