Bio-absorbable materials in the treatment of fractures

Abstract

Event Abstract Back to Event Bio-absorbable materials in the treatment of fractures P Givissis1* 1 Aristotle University of Thessaloniki, 1st Department of Orthopaedics, Greece The internal fixation devices used in Orthopaedic surgery serve no purpose as soon as they have fulfilled their mission of securing the healing and union of the tissues concerned. Osteosynthesis restores bone stiffness temporarily, while fracture healing restores it permanently. In internal fixation, the implant of choice is still metal, which offers high stiffness, good ductility and is biologically well tolerated. Biodegradable implants have only limited indications due to their mechanical properties which can resist only minor loading. The ideal implant would be made of a bioabsorbable material, which: -has appropriate initial strength to meet the biomechanical demands -degrades in a predictable fashion, remaining sufficiently strong until the bone is healed -causes no deleterious tissue responses -disappears completely. Most absorbable fixation materials are composites of polyglycolic acid (PGA) and polylactate acid (PLA) that attain the benefits of each material while limiting the disadvantages. Specific composition depends on manufacturer as well as on application. The conversion from traditional metal implants to more biological non-metallic devices is taking place at an accelerating pace. Biomechanical studies on fresh frozen bones have shown that the fixation rigidity achieved with self-reinforced devices approaches that of metallic osteofixation methods. The reliability of modern implants has been confirmed in several experimental and clinical studies. Keywords: bio-absorbable implants, fractures, implant safety Conference: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010, Thessaloniki, Greece, 1 Oct - 5 Oct, 2010. Presentation Type: Oral Topic: Food, drugs and environmental xenobiotics Citation: Givissis P (2010). Bio-absorbable materials in the treatment of fractures. Front. Pharmacol. Conference Abstract: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010. doi: 10.3389/conf.fphar.2010.60.00124 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Mar 2011; Published Online: 04 Nov 2010. * Correspondence: Dr. P Givissis, Aristotle University of Thessaloniki, 1st Department of Orthopaedics, Thessaloniki, Greece, akritop@yahoo.gr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers P Givissis Google P Givissis Google Scholar P Givissis PubMed P Givissis Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.