Binuclear Cu(II) Schiff base complexes as prescursors for the synthesis of CuO nanoparticles: anticancer activity against MCF-7 cell line

Abstract

Homobinuclear Cu(II) complexes 1 and 2 were synthesized and characterized by elemental analysis, FTIR, 1H NMR, Mass, UV–vis, magnetic moment, ESR and TGA studies. The synthesized complexes 1 and 2 were used as precursors for the synthesis of CuO Nps by calcination method. CuO Nps were characterized by FTIR, XRD, scanning electron microscopy (SEM), and EDX. XRD peaks clearly indicated the monoclinic structure of CuO. CuO nanoparticles were synthesized with average particle size 3–4 and 5–10 nm. The morphologies and size of the obtained products were further investigated by SEM. Presence of essential constituents of CuO Nps was investigated by EDX studies. The Anticancer activity of the precusors 1&2 and its nanoparticles have been analyzed against the MCF-7 cell line by MTT assay. The Precusor 1 with IC50 value 12.66 μM was found to have high anticancer activity than other compounds.Synopsis:Binuclear Cu(II) Schiff base complexes 1 & 2 were synthesized from the ligands L1 and L2, respectively.Binuclear Cu(II) complexes were successfully used as a precursor for the synthesis of CuO Nps.The ligands, precusors, and the CuO Nps were analyzed for their anticancer activity against the MCF-7 cell line.Precursor 1 synthesized from the ligand L1 shows high activity than other compounds due to the presence of the heterocyclic moiety.