Binocular Summation of Visual Acuity at High and Low Contrast in Early Glaucoma.

Abstract

This study examined the integrity of binocular summation function in patients with mild glaucoma. We found that binocular summation of visual acuity is preserved in these patients, despite their reduced monocular inputs. Binocular summation represents superiority of binocular to monocular performance. In this study we examined the integrity of binocular summation function in patients with early glaucoma who had structural glaucomatous changes but otherwise had no significant interocular acuity asymmetry or other functional deficit detected with standard clinical measures. Participants included 48 patients with early glaucoma according to Hodapp, Anderson, and Parrish 2 (HAP2) criteria (age 65±12y) and 42 healthy controls (age 60±12y), matched for stereoacuity. Visual acuity was assessed binocularly and monocularly at high (95%) and low (25%) contrast using the Early Treatment Diabetic Retinopathy Study (ETDRS) charts at 6m. Binocular acuity summation was evaluated utilizing a binocular ratio (BR). Overall, binocular and monocular visual acuity of the control group was better than that of the glaucoma group for both contrast levels, P =0.001. For the glaucoma group, there was a significant difference between BRs at high and low contrast, 0.01±0.05 and 0.04±0.06 ( P =0.003), respectively. For the control group, the difference between BR at high and low contrast was not statistically significant, 0.00±0.07 and 0.02±0.06 ( P =0.25), respectively. For patients with early glaucoma, binocular summation function for visual acuity was preserved at both contrast levels. This suggests an adaptation of the visual system in early stages of glaucoma that allows for normal binocular summation in the presence of reduced monocular visual input.