Abstract
A new study proposes an integrated framework to improve our understanding of the multiple functions of insulator elements, and their architectural role in the genome.See related research; http://genomebiology.com/2014/15/6/R82
Highlights
A new study proposes an integrated framework to improve our understanding of the multiple functions of insulator elements, and their architectural role in the genome
The best formulation so far, based largely on Su(Hw), was offered by Capelson and Corces [2], who proposed that insulatorbinding complexes interact with one another through the ‘glue’ proteins CP190 and Mod(mdg4), organizing genomic chromatin into loops radiating from clusters of interacting insulator elements
It has been shown that cohesin binding at CTCF binding sites depends on CTCF and that cohesin is required for CTCF insulator function
Summary
A new study proposes an integrated framework to improve our understanding of the multiple functions of insulator elements, and their architectural role in the genome. CP190 and isoforms of Mod(mdg4), are known to interact with insulator-binding factors and are recruited to many, but not all, of their binding sites. The best formulation so far, based largely on Su(Hw), was offered by Capelson and Corces [2], who proposed that insulatorbinding complexes interact with one another through the ‘glue’ proteins CP190 and Mod(mdg4), organizing genomic chromatin into loops radiating from clusters of interacting insulator elements.
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