Binding Proteins of Protein Therapeutics

Abstract

Numerous examples of binding proteins for protein therapeutics have been reported. Binding proteins have been shown to exist for insulinlike growth factors I and II, tissue plasminogen activator, growth hormone, deoxyribonuclease I, tissue factor, nerve growth factor, transforming growth factor-β I and II, as well as others. Binding proteins may have either inhibitory or stimulatory effects, may modulate efficacy at the cellular level, and may also affect the pharmacokinetics and metabolism of protein therapeutics. Furthermore, the relative importance of binding proteins may be species or disease state specific. It is also important to realize that binding proteins may play a different role in the regulation of proteins when physiological concentrations of proteins are involved compared to pharmacological doses of protein therapeutics. The pharmacology, physiology, regulation, and interactions of binding proteins with their target proteins will be discussed. This review chapter will focus on insulinlike growth factor, tissue plasminogen activator, and growth hormone.KeywordsGrowth HormonePlasminogen ActivatorPlasminogen Activator InhibitorProtein TherapeuticsGrowth Hormone ReceptorThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.