Abstract
The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki=0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for α1 and D1 receptors (Ki=17 and 41 nM, respectively). However, SM-9018 had only negligible affinity for α2, opiate, glutamate, phencyclidine, benzodiazepine and GABAA receptors. These results suggest that SM-9018 may be a novel antipsychotic agent with binding affinity for 5-HT2 and 5-HT1A receptors.
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