BINDING OF THE AB43 PEPTIDE TO APOLIPOPROTEIN E AND ITS ROLE IN CLEARANCE

Abstract

previously associated with AD including tau, apolipoprotein E, complement C1q, neuroligin and heat shock proteins. Studies are ongoing to determine which proteins have altered expression in AD tissue from patients at early versus late stages of disease and tissue from normal age-matched controls. Conclusions: The combined use of laser capture microdissection and LCMS to characterize proteins in specific brain structures or cell types has great promise for future studies. Future results using this technique will complement those from GWAS studies, potentially identifying protein pathways uniquely expressed or altered in AD. The function of these identified proteins and consequences of expression in AD can then be pursued in further research and could provide novel therapeutic targets.