Abstract
The immunochemical and functional properties of IgG fractions from patients with Lambert-Eaton myasthenic syndrome (LEMS) were examined in chick and rat synaptosomes. LEMS IgG immunoprecipitated 125I-ω conotoxin GVIA ( 125I-ωCgTx) labeled N-type calcium channels solubilized from both tissues, and reacted with a 65 kDa protein band in immunoblots of rat synaptosomes. Depolarization-induced 45C 2+ influx into chick synaptosomes was partially inhibited by ωCgTx, whereas influx into rat synaptosomes was insensitive to ωCgTx. No effect of LEMS sera or IgG on 45Ca 2+ uptake was apparent in either preparation.
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