Abstract
Patellamide D, a cyclic octapeptide from the ascidian Lissoclinum patella with two oxazoline and two thiazole rings, has a 24-azacrown-8 macrocyclic structure. It forms a mononuclear Cu(II) complex in methanol and acetonitrile with one peptide amide deprotonated, and a binuclear Cu(II) complex with two peptide amides deprotonated. In methanol a third deprotonation occurs and this has been interpreted as solvent deprotonation to form a bridge between the two Cu(II) ions. The electronic absorption, CD and ESR spectra will be reported as a function of added base. A Cu(II)-Zn(II) complex has also been formed and its spectroscopic data will also be reported.
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