Abstract
The binding of Cu(II) and Mn(II) to 9-methylpurine has been examined by proton NMR and potentiometric titration. The spin-lattice relaxation rates of ring protons H2, H6 and H8, used as input to the Solomon-Bloembergen equation, give a binding pattern which qualitatively agrees with crystallographic data. At neutral pH Cu(II) and Mn(II) binding occurs at both N1 and N7 with a preference for N7 (66%). At acidic pH, where N1 is the predominant protonation site, a further shift towards N7 binding is observed. These results are not in complete agreement with those based on comparison of N1/N7 basicity.
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