Abstract
[ 3H]desipramine. a labeled tricyclic antidepressant, binds specifically to rat brain crude synaptosomal and membranal preparations. The binding is rapid, displaceable and saturable with a IC 50 value of 4 × 10 −6M. The maximal number of sites is 18–26 nmoles/g original tissue in the synaptosomal preparation and only 6–8 nmoles/g in the membranal preparation. Scatchard plots of the binding data are not linear, suggesting a heterogenous set of binding sites. Pargyline and a number of neurotransmitters and agonists have only a small effect on desipramine binding; whereas various neurotransmitter antagonists inhibit the binding at the μM concentration range.
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