Abstract
Methyl trienolone (R 1881 —17β-hydroxy-17α-methyl-estra-4, 9, 11-trien-3-one) binding to rat ventral prostate cytosol has a specificity typical of an androgen receptor. In human benign prostatic hypertrophy (BPH) tissue, the specificity of [ 3H] R 1881 binding is different from that measured in rat prostate: progesterone and R 5020 (17, 21-dimethyl-19-nor-4, 9-pregnadiene-3, 20-dione) being more potent while 19-nortestosterone is less potent competitor. Moreover, the synthetic progestin [ 3H] R 5020 binds to BPH tissue with a similar specificity. These data suggest the presence of progestin bindng components or of an atypical androgen receptor in human BPH cytosol.
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