Binding Kinetics for Biosensor Applications Utilizing Fractals: A Categorization

Abstract

Analyte–receptor binding reactions occurring on biosensor surfaces are categorized using a fractal analysis. Both a single- and a dual-fractal analysis are utilized to describe the analyte–receptor binding kinetics. The three categories presented to describe the binding kinetics include (a) case I—only a single-fractal analysis is utilized, (b) case II—a single- and a dual-fractal analysis are utilized (implying a change in the binding mechanism), and (c) case III—only a dual-fractal analysis is utilized. This is an initial attempt to categorize surface binding kinetics. The categorization provides one possible means of classifying analyte–receptor reactions occurring on biosensor surfaces. The analysis should help to improve biosensor performance parameters. The analysis is, in general, extendable to analyte–receptor reactions occurring on other surfaces.