Abstract
In this study, we performed characterization of a new class of drug delivery system (DDS), named magnetic nanoemulsion (MNE), which allows the combined action of local hyperthermia (HPT) and photodynamic therapy (PDT), designed to work in a synergic way as promising cancer therapies. The MNEs were prepared using maghemite magnetic nanoparticles surface coated with phosphate (PPT) and the photosensitizer (PS) zinc phthalocyanine (ZnPc). Photophysical properties of the MNEs were studied by time-resolved spectroscopic techniques. Values of K b( n) found for PPT with HSA and BSA were 1.44×10 8 M −1 (1.32) and 1.38×10 8 M −1 (0.93), respectively. The values for triplet quantum yields ( Φ T) found were 0.57 and 0.56 for NE/ZnPc and MNE/ZnPc/PPT, respectively. The values obtained in the present study establish excellent achievements as far as the PDT treatment is concerned.
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