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Abstract
The interfacial works of cohesion and adhesion (between substrate and binder) in addition to the spreading coefficients of one phase on the other have been calculated for a number of pharmaceutical solids and polymeric binders using literature values of surface free energies and polarities. For low polarity substrates (polarity < 0.2) calculations have shown that polyvinyl pyrrolidone or starch would be the optimum binder while for higher polarity substrates (polarity > 0.4) the cellulose derivatives or acacia would be the optimum binder, consistent with the trends reported in the literature. The spreading coefficients have implications in that it is possible to hypothesise two distinct modes of granule formation.
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