Abstract
When binary responses are observed over time, the dependence between observations for an individual must be considered. If the focus of a study is to identify the relationship between the binary response and a set of explanatory variables then the dependence between observations may also depend on the explanatory variables. An extension of a model where dependence is assumed to be constant will be considered. A model previously proposed for dependent binary responses will be revisited and a robust estimate of the variance-covariance matrix of coefficient estimates will be suggested to provide estimates of standard errors. The results of simulation studies investigating the properties of coefficient estimates will be discussed. An example based on a study of the AIDS epidemic and intravenous drug use behaviour will be analyzed to illustrate the techniques.
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