Binary and ternary Cu(II) complexes of pregabalin with excitatory and inhibitory neurotransmitters and their antiepileptic effect.

Abstract

Antiepileptic drug (Preg) and neurotransmitters (Gpn, Gly, Asp, Glu, Ser, GABA and Ade) were used to synthesis a series of ternary Cu2+ complexes. Surface morphology and chemical composition of the complexes were using studied SEM and EDX spectra. Purity, molecular weight and formulae of the complexes were determined from GC-MS spectra and elemental analysis. XRD data and N-Treor implemented in Expo2014 computer program reveal monoclinic crystal system with space group P1 2/c 1 and P 1 21 1 of the complexes. IR spectra exhibited that Preg, Gpn and GABA coordinated to the Cu2+ as monodentate ligand through COOH whereas the amino acids bonded through the -NH2, COO- groups. UV-Vis spectra and magnetic moment values indicated pseudo tetrahedral stereochemistry. ESR spectra showed that the complexes have isotropic and axial structures with dx2-y2 ground state. TGA, DTG and DTA confirm the suggested structure and mechanism for thermal decomposition was suggested. Kinetic and thermodynamic parameters were calculated using Coats-Redfern equation. The complexes [Cu(Preg)(Ser)Cl] and [Cu(Preg)(Ade)Cl2] showed greater anticonvulsant activity compared against PTZ-induced seizures in male Albino mice. Recorded latency time for the complexes [Cu(Preg)(Ser)Cl] and [Cu(Preg)(GABA)(OH)Cl].2H2O was longer than that recorded with Preg indicating higher anticonvulsant effect.