Abstract
The occurrence of two dissimilar categories of malignant lymphoma arising within an individual in a sequential manner or as a simultaneous event incriminating the aforementioned lymph node groups may be infrequently elucidated.
Highlights
Composite lymphoma as an entity was initially described by Custer et al followed by a modified delineation by Hicks et al and Kim et al with a categorical emergence of architecturally diverse and binary cytological subcategories of lymphoma within the same anatomic site or tissue
A heterogeneous manifestation of B cell markers localized within the components of diffuse large B cell lymphoma (DLBCL)and nodular lymphocyte predominance Hodgkin’s lymphoma (NLPHL) may arise, all (100%) of the nodular (NLPHL) fraction may delineate a B cell phenotype
The genetic amalgamation of immunoglobulin heavy chain (IgH) rearrangement with BCL2 recombination may be localized within the enlarged cells of composite lymphoma- a follicular lymphoma and a diffuse lymphoma (DLBCL) constituting the condition. (Figure 9) A fluorescent in situ hybridization (FISH) may demonstrate the MYC gene rearrangements detected within the diffuse lymphoma (DLBCL), which may be lacking in the follicular lymphoma (FL) component of the composite admixture
Summary
Composite lymphoma as an entity was initially described by Custer et al followed by a modified delineation by Hicks et al and Kim et al with a categorical emergence of architecturally diverse and binary cytological subcategories of lymphoma within the same anatomic site or tissue. The nodular tumour fraction (NLPHL) of the composite lymphoma indicates the low-grade component and a progression to a large B cell lymphoma, as may be evidenced by the immune histochemical elucidation of the Reed Sternberg (RS) cells confined to the lymphocyte predominant (NLPHL) subsection which may be immune reactive for B cell markers [7,8]. A heterogeneous manifestation of B cell markers localized within the components of diffuse large B cell lymphoma (DLBCL)and nodular lymphocyte predominance Hodgkin’s lymphoma (NLPHL) may arise, all (100%) of the nodular (NLPHL) fraction may delineate a B cell phenotype.
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