Bimetallic homoleptic divalent metal-complexes of diisatin dihydrazone ligand. Biological activity and catalytic oxidation of sulfides

Abstract

According to the significant role of transition metals in their metallo-organic frameworks catalytically and biologically, two new dinuclear homoleptic complexes of Pd2+ and VO2+ ions (PdLC2 and VOLC2, respectively) with succinyl dihydrazone diisatin ligand (H2LC2) were constructed. The effect of the M2+ ion type was distinguished in the productive redox protocol of diphenyl sulfide (DiPhS) and methylphenyl sulfide (MePhS) within H2O2. Considerable productivity was assigned by the yielding percentages of diphenyl sulfoxide (DiPhSO) and methylphenyl sulfoxide (MePhSO) (the mono-oxo-selective product) catalyzed by PdLC2 or VOLC2, in which VOLC2 catalyst exhibited little more classified efficiency than that of PdLC2, referring to the progressed redox potential of V4+ ion in VOLC2 catalyst.Their biological performance was recorded based on their inhibited potential against the growing power of some cancer/normal cells of humans, bacteria, as well as, fungi. The bio-studies appointed the role and job of M2+ ion (Pd2+ or VO2+ ion) in its chelated MLC2 complex over the free ligand, H2LC2. Moreover, their interacted modes with ctDNA (i.e. calf thymus DNA) were examined via the viscometries and spectrophotometric titration. Since the two chelates (PdLC2 and VOLC2) represented an attractive performance for the inhibited action for the current microorganisms and the cancer cell lines of humans’ growth over the free H2LC2 ligand. PdLC2 and VOLC2 complexes displayed an appreciable reaction with ctDNA more than that of their free organo-ligand H2LC2. From the binding constant (Kb) and Gibb’s free energy (ΔGb≠) values, both PdLC2 and VOLC2 exhibited more binding interaction within ctDNA than that of the H2LC2 ligand, with the progressed Lewis acidity, electronegativity, and lipophilic feature (hydrophobicity).