Abstract
The biliary excretion of carbenicillin was studied in three different ways—in the experimentally perfused rabbit liver, in normal subjects following duodenal intubation and in cholecystectomized patients with external biliary drainage In all of these circumstances the biliary concentration of carbenicillin parallels the serum level of antibiotic very closely. On account of the weak or non-existent antibiotic activity in hepatic tissue at the end of the perfusion procedure the hypothesis is put forward that carbenicillin is inactivated by the rabbit liver. The high biliary concentrations of carbenicillin obtained following the administration of the antibiotic in relatively modest doses would favour its use in the treatment of biliary infections.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
