Abstract
87.9% of a given dose of [ 3H]Norethisterone ([ 3H]N) and 76.7% of [ 3H]Ethinyloestradiol ([ 3H]EE 2) were excreted in the bile of male heterozygous Gunn rats in 2 hours Similarly, 86.9% of a given dose [ 3H]N and 84.0% of [ 3H]EE 2 were excreted in the bile of male homozygous Gunn rats in 2 hours. In both heterozygous and homozygous rats glucuronide conjugates were present. Despite the lesion in UDP-glucuronyltransferase, the homozygous rats is able to conjugate the synthetic steroids apparently normally.
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