Abstract

Biliary adenofibroma is a rare benign liver tumor with potential for malignant transition. It has a bile duct origin characterized by a complex tubulocystic biliary epithelium with fibrous stroma. MRI features may suggest this uncommon entity, and histological findings can be diagnostic. We report a case of biliary adenofibroma with transformation to an intrahepatic cholangiocarcinoma.

Highlights

  • Biliary adenofibroma is an extremely rare hepatic tumor

  • We report a case of biliary adenofibroma with malignant transformation

  • The carcinomatous component of the tumor showed a complex architecture with crowded back-to-back anastomosing and cribriform-like tubules

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Summary

Introduction

Biliary adenofibroma is an extremely rare hepatic tumor. It has similar histological components as von Meyenburg complexes and is classified as a benign tumor. Biliary adenofibromas are larger and have the potential for malignant transformation [1,2,3,4,5,6,7]. We report a case of biliary adenofibroma with malignant transformation

Case presentation
Pathological findings
Immunohistochemistry and Genetic Analyses
Discussion
Conclusion

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