Abstract
The effect of conjugated dihydroxy and trihydroxy bile salts on electrolyte transport across isolated rabbit jejunal mucosa was studied. Both taurochenodeoxycholic acid and taurocholic acid increased the short-circuit current ( I sc ) in bicarbonate-Ringer solution but not in a bicarbonate-free, chloride-free solution. Taurochenodeoxycholic acid was significantly more effective than taurocholic acid in increasing I sc . The presence of theophylline prevented the taurochenodeoxycholic acid-and taurocholic acid-induced increase in I sc . Transmural ion fluxes across jejunal mucosa demonstrated that 2 mM taurochenodeoxycholic acid decreased net Na + absorption, increased net Cl − secretion and increased the residual flux (which probably represents HCO 3 − secretion). These studies support the hypothesis that cyclic AMP may be a mediator of intestinal electrolyte secretion.
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