Abstract
Bile and pancreatic juice vary in their trypsin inhibitor content. Activation of bile-pancreatic juice mixtures (1:1) occurred when the combined trypsin inhibitory capacity was low. No activation was seen with bile having a high trypsin inhibitor content. Pancreatic juice activated faster where more trypsin inhibitor complex was present. With calcium (25 mM), pancreatic secretions activated in a similar order as with the trypsin-inhibitor-free bile. We propose that activation occurs more readily where large amounts of the trypsin-inhibitor complex are present in pancreatic juice as a result of carcinoma or other etiologies.
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More From: Biochemical and Biophysical Research Communications
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