Abstract
The damaging effect of human bile on the gastric mucosal barrier has been studied in 3 dogs with Heidenhain pouches. Transmucosal potential difference (PD) and net fluxes of sodium and hydrogen ion have been examined before, during, and after contact with bile solutions at pH 2, 4, and 8 and bile acid concentrations of 20, 10, 5, and 0 mM. Bile caused a profound fall in PD which partly recovered during the test. Changes in PD were greatest at the highest concentrations of bile but were not significantly different with solutions of different pH. H+ back diffusion from, and Na+ gain by, the pouch were significantly increased after contact with higher bile concentrations and in the case of H+ ion this effect was greatest at pH 2 and least at pH 8. The increased Na+ output was not accompanied by a proportionate increase in fluid volume, suggesting that this effect was a result of ionic diffusion rather than secretion of a hypothetical nonparietal component.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
