Abstract
The advantages of a treatment modality that combines two or more therapeutic agents in cancer therapy encourages the study of hybrid functional compounds for pharmacological applications. In light of this, we reviewed recent works on hybrid molecules based on bile acids. Due to their biological properties, as well as their different chemical/biochemical reactive moieties, bile acids can be considered very interesting starting molecules for conjugation with natural or synthetic bioactive molecules.
Highlights
IntroductionUDCA and TUDCA (that is, the taurine conjugated of UDCA, Figure 1C)) show cytoprotective and chemopreventive effects, and UDCA exhibits weak to moderate anticancer activity in vitro when used at high concentrations [17]
We focus on BA hybrids with potential anticancer activity reporteIdn itnhilsitsehroartturreeviinewth, we leafsotctuesnoyneBarAs,haynbdridwsewsihtharpeostoemntieaul annptuicbalniscehreadcrtievsiutyltrsefproormtedouinr rlietseeratrucrheginrothuepl.ast ten years, and we share some unpublished results from our research group
The current review reported recent developments in the chemistry and biology of a particular group bioconjugates based on bile acid derivatives in the hope of motivating the further development of this family of molecules
Summary
UDCA and TUDCA (that is, the taurine conjugated of UDCA, Figure 1C)) show cytoprotective and chemopreventive effects, and UDCA exhibits weak to moderate anticancer activity in vitro when used at high concentrations [17] Due to their peculiar physical-chemical and biological properties, together with the ease of carrying out chemical modification of hydroxyl and carboxyl groups, BAs have gained significant attention with respect to their use for the molecular hybridization of natural/synthetic and drug/nondrug scaffolds to design new compounds to improve the bioavailability [18], metabolic stability and intestinal absorption of parent compounds [19,20].
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