Bilateral Thalamic Glioblastoma Multiforme with Synchronous Asymptomatic Bone Metastasis- A Rare Case Report

Abstract

Bilateral Glioblastoma multiforme (GBM) at the thalamus is an extremely rare condition accounting for 1-2% of brain tumors. Extra-cranial metastases of GBM are rare due to the absence of lymphatics in the brain and the difficulty of tumors penetrating blood vessels. Moreover, these metastatic lesions remain asymptomatic and are often identified during autopsy. Hereby, a case of a rare presentation of bilateral thalamic GBM with synchronous asymptomatic bone metastasis to the humerus treated using Radiation therapy to both bilateral thalamic lesions and humerus bone metastasis with concurrent and adjuvant temozolomide-based chemotherapy is reported.