Abstract
In the cat two asymmetrical foci were created by injection of cobalt-alumina intracortically. After an initial period of asynchronous epileptic activity, time-locked discharges represented the EEG pattern until death 2–4 months after surgery. In about 50% of cats bilaterally synchronous and symmetrical spike and wave or poly-spike and wave discharges occurred, accompanied by massive myoclonic jerks. The error of interhemispheric synchrony was 50–100 msec. Splitting the corpus callosum and hippocampal commissure disrupted bilateral synchrony which. on the contrary, was not affected by cortical-callosal isolation. The role played by commissural pathways and by cortical-subcortical pathways and subcortical structures in mediating functional interaction between the chronic asymmetrical foci is discussed.
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