Abstract
BackgroundDepression comorbid with posttraumatic stress disorder (PTSD) can be disabling and treatment resistant. Preliminary evidence suggests that repetitive transcranial magnetic stimulation (rTMS), may have a role in helping these patients. There are only few published studies using different rTMS paradigms including bilateral intermittent theta burst (iTBS) and low frequency rTMS.MethodsIn this small cohort observation study, we examined the efficacy of bilateral sequential theta-burst stimulation (bsTBS) in 8 treatment resistant depression (TRD) military veterans with PTSD comorbidity stemming from military service experience.ResultsbsTBS was generally well tolerated and resulted in 25% and 38% remission and response rates on Depression scores respectively; 25% remission and response rate on PTSD scores.DiscussionThis study demonstrates preliminary feasibility and safety of bsTBS in TRD with comorbid military service related PTSD.We concluded that this paradigm might hold promise as a therapeutic tool to help patients with TRD co-morbid with military service related PTSD. Further adequately powered studies to compare rTMS treatment paradigms in this patient group are warranted.
Highlights
Posttraumatic stress disorder (PTSD) can be comorbid with other illnesses and can cause significant impairment [1]
We concluded that this paradigm might hold promise as a therapeutic tool to help patients with treatment resistant depression (TRD) co-morbid with military service related posttraumatic stress disorder (PTSD)
A recent study by Philip et al [7] showed that repetitive transcranial magnetic stimulation (rTMS), at 5-Hz, was superior to intermittent theta burst (iTBS) in the treatment of PTSD symptoms when
Summary
Posttraumatic stress disorder (PTSD) can be comorbid with other illnesses and can cause significant impairment [1]. Repetitive transcranial magnetic stimulation (rTMS) is a relatively non-invasive procedure increasingly used to treat psychiatric disorders. Two studies examined iTBS in PTSD and showed a reduction in depression and PTSD symptoms [5, 6]. A recent study by Philip et al [7] showed that rTMS, at 5-Hz, was superior to iTBS in the treatment of PTSD symptoms when. Depression comorbid with posttraumatic stress disorder (PTSD) can be disabling and treatment resistant. Preliminary evidence suggests that repetitive transcranial magnetic stimulation (rTMS), may have a role in helping these patients. There are only few published studies using different rTMS paradigms including bilateral intermittent theta burst (iTBS) and low frequency rTMS
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
