Abstract
Background. The risk of ovarian cancer is increased in the association of ovarian tumor, ascites, and hydrothorax with the significant elevated tumor marker CA-125. However, this association can be observed in a rare clinical and benign pathological entity, that is Demons-Meigs' syndrome. Objective. To describe a rare case of Demons-Meigs' syndrome observed in our department. Methods. A black African woman of 35 years old, seventh gravida and fourth parous, underwent a total abdominal hysterectomy with bilateral salpingoophorectomy for large bilateral ovarian masses associated with significant ascites, bilateral pleural effusion, and particular highly elevated tumor marker CA-125 (1835 UI/mL) in a pronounced general alteration condition. Results. The postoperative course was uneventful characterized by a complete remission of hydrothorax and ascites with normal level of CA-125 three months after tumor excision. Histology of both masses revealed a bilateral ovarian fibrothecoma, a benign tumor of the ovary, thus confirming the diagnosis of Demons-Meigs' syndrome. Conclusion. The Demons-Meigs syndrome, although it strongly mimics the clinical picture of malignant metastatic ovarian cancer, remains a disease with benign prognosis after surgical tumor resection. This is a rare condition that must be known and recognized by practitioners to avoid unnecessary practices.
Highlights
The Demons-Meigs syndrome (DMS) in its initial typical form is a pathology that combines ovarian fibroma or fibrothecoma, ascites, and hydrothorax [1]
The Demons-Meigs syndrome, it strongly mimics the clinical picture of malignant metastatic ovarian cancer, remains a disease with benign prognosis after surgical tumor resection
Its incidence is difficult to determine, it was noted that the ovarian fibroma represents 2–5% of all ovarian tumors and the incidence of DMS among patients with ovarian fibroma is estimated between 1% and 3% [3, 4]
Summary
The risk of ovarian cancer is increased in the association of ovarian tumor, ascites, and hydrothorax with the significant elevated tumor marker CA-125 This association can be observed in a rare clinical and benign pathological entity, that is Demons-Meigs’ syndrome. The postoperative course was uneventful characterized by a complete remission of hydrothorax and ascites with normal level of CA-125 three months after tumor excision Histology of both masses revealed a bilateral ovarian fibrothecoma, a benign tumor of the ovary, confirming the diagnosis of Demons-Meigs’ syndrome. The Demons-Meigs syndrome, it strongly mimics the clinical picture of malignant metastatic ovarian cancer, remains a disease with benign prognosis after surgical tumor resection This is a rare condition that must be known and recognized by practitioners to avoid unnecessary practices
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