Abstract
BackgroundAcute myeloid leukemia is typically a disease of the older population and presents mostly in the fifth decade of life. Myeloid sarcoma is a rare initial presentation of acute myeloid leukemia. Previously it has only been documented in children and younger patients.Case PresentationWe present an unusual case of retro-orbital myeloid sarcoma as an initial presentation of acute myeloid leukemia in a 43-year-old Caucasian man, with rearrangement of chromosome 11q23 involving the MLL gene.ConclusionsWe present an unusual case of retro-orbital myeloid sarcoma as an initial presentation of acute myeloid leukemia in a 43-year-old man, with rearrangement of chromosome 11q23 involving the MLL gene.
Highlights
Acute myeloid leukemia is typically a disease of the older population and presents mostly in the fifth decade of life
To the best of our knowledge, since 1993 a total of 11 cases of granulocytic sarcoma (GS) preceding Acute myeloid leukemia (AML) in adults have been reported [10, 20,21,22,23,24,25,26,27], most of them presenting with the cytogenic t(8:21) translocation and a fair prognosis
We describe a very aggressive case of AML positive for CD34 and CD117 and a rearrangement of chromosome 11q23 involving the MLL gene that resulted in death
Summary
Acute myeloid leukemia (AML) is generally a disease of older population with an average age of presentation of 66 years. Case presentation A 43-year-old Caucasian man presented to our emergency room with frontal headache and blurred vision He had a recent history of surgically excised malignant melanoma of the right cheek and right-sided Bells’ palsy treated with acyclovir and steroids. A neurological examination revealed weakness in adduction of his left eye with complete ptosis (likely due to left third nerve palsy), ipsilateral conjunctival injection and dilated pupil, a depressed nasolabial fold on the left side, and drooping of the angle of his mouth to the left with drooling (representing left seventh nerve palsy) His deep tendon reflexes were decreased to 1+ in his upper and lower extremities along with generalized decreased sensation to pin prick and light touch.
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