Bilateral multifocal retinal arteriolar sheathing as the only ocular finding in hereditary amyloidosis

Abstract

To report the early ocular findings in hereditary amyloidosis. Case report of a visually asymptomatic, 52-year-old Mexican man with systemic manifestations of amyloidosis (peripheral neuropathy, restrictive cardiomyopathy), with a positive family history, and with amyloid on an endomyocardial biopsy specimen, who had bilateral multifocal sheathing or cuffing of the peripheral retinal arterioles. An extensive evaluation for retinal vasculitis was discontinued when hereditary amyloidosis was diagnosed. Focal retinal periarteriolar plaques of amyloid may be the earliest and only ocular finding of hereditary amyloidosis.