Abstract
Bilateral jugular veins occlusion in mice: Clinical and histological findings
Highlights
It was hypothesized that an alteration of venous outflow could be associated to many diseases [1,2,3,4,5,6,7,8,9,10,11]
We have developed a mice model of cerebral blood outflow obstruction obtained through the bilateral ligation of the internal and external jugular veins [26] that might reproduce intracerebral venous stasis similar to that observed in patients with internal jugular vein obstruction
Thirtyeight (18female/20male) 8-12 weeks-old C57/black mice were used for our experiments, 22 mice underwent to the bilateral ligation of the internal (IJV) and external Jugular veins (EJV) (“ligated group” Ligated group (LG)), 16 mice underwent to the same operative procedures and postoperative precautions but without jugular veins ligation (‘‘sham-operated group’’ Sham group (SG))
Summary
It was hypothesized that an alteration of venous outflow could be associated to many diseases [1,2,3,4,5,6,7,8,9,10,11]. The development of animal models of cerebral veins obstructions might contribute to better evaluate and understand the effects of chronic cerebral outflow obstruction on functional, biochemical and morphological alterations of brain tissues. To the best of our knowledge, only two papers described the effect of ligation of neck veins in mice [23,24], but these studies took in consideration only the ligature of the external Jugular veins. We have developed a mice model of cerebral blood outflow obstruction obtained through the bilateral ligation of the internal and external jugular veins [26] that might reproduce intracerebral venous stasis similar to that observed in patients with internal jugular vein obstruction
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