Abstract
We present the diagnosis of bilateral granulomatous inflammation of the hip joints associated with Hylan G-F 20 viscosupplementation injections. Clinicians recommending therapeutic Hylan injections for the management of hip arthritis should maintain clinical awareness regarding this potential complication.
Highlights
Viscosupplementation injections for the management of osteoarthritis of the hip have been demonstrated to be both safe and effective [1–9]
We present the first description of Hylan induced granulomatous inflammation within the hip joint
Granulomatous inflammation associated with viscosupplementation in the knee joint was described by Chen et al [16] in six patients with chronically inflamed synovium with histiocytic foreign body giant cell reactions observed on microscopy
Summary
Viscosupplementation injections for the management of osteoarthritis of the hip have been demonstrated to be both safe and effective [1–9]. Acute injection related synovitis is observed in approximately 5–10% of patients undertaking this treatment, but these reactions are characteristically transient without longer-term clinical effects [10–15]. Chronic granulomatous inflammatory synovial reactions associated with Hylan injections have been described within the knee joint as an infrequent occurrence [11, 16, 17]. We present the first description of Hylan induced granulomatous inflammation within the hip joint
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