Bilateral changes in soma size of geniculate relay cells and corticogeniculate cells after neonatal monocular enucleation in rats

Abstract

Some areas of relay cells of the lateral geniculate nucleus and of corticogeniculate cells of normal rats (n= 4) were compared with those of neonatally unilaterally eye-enucleated adult rats (n= 13). These cells were labeled by retrogradely transported HRP. Monocular enucleation was performed on postnatal days 1 (PND 1) (n= 4), 3 (PND 3), (n= 5) and 6 (PND 6)_(n= 4). The resulsts are summarized as follows. (1) In PND 1 rats soma areas of relay cells were 12–16% smaller than those of normal rats, but only for the geniculate nucleus ipsilateral to the remaining eye. In PND 3 and 6 rats the areal shrinkage of relay cells was 27–39% of the normal control for both hemispheres, though it was less marked in the hemisphere contralateral to the remaining eye. (2) The corticogeniculate cells were distributed in layers V and VI in eye-enucleated rats as well as in normal rats. Soma areas of both layer V and VI cells increased in PND 1 rats for both hemispheres by about 15–47% of the normal control. InPND 3 rats increase in soma size tended to occur for layer VI cells, although the data varied from animal to animal. In summary, it was established that unilateral eye-enucleation in rats at birth induced soma size changes of the geniculate relay cells and of the corticogeniculate cells in the non-deafferented as well as in the deafferented hemisphere. Possible mechanisms for the bilateral changes in soma area of central visual cells after neonatal monocular enucleation are discussed.