Abstract
Normal rats previously tested for rotation (circling behavior) were injected with either haloperidol (0.125 mg/kg) or vehicle and their brains analyzed bilaterally for striatal dopamine metabolites. DOPAC was significantly higher in the striatum ipsilateral to the dominant direction of rotation for vehicle-treated animals, and contralateral for those receiving haloperidol. It was concluded that haloperidol has a bilateral asymmetrical action on nigrostriatal pathways which may be related to its clinical pharmacotherapeutic effectiveness.
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