Big Data Information under Proportional Hazard Mathematical Model in Analysis of Hepatitis B Virus Infection Data of Patients with Interventional Liver Cancer through Antiviral Therapy of Entecavir.

Yichi Zhang,Jian Wang,Xuya Cui,Bing Han,Han Ding,Xiaoling Song,Shuai Zhao,Huijie Miao,Enas Abdulhay

doi:10.1155/2021/6225403

Yichi Zhang, Jian Wang + Show 7 more

Open Access

https://doi.org/10.1155/2021/6225403

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Abstract

The objective of this study was to analyze the application of proportional hazard mathematical model (PHMM) in Hepatitis B Virus (HBV) infection analysis of interventional liver cancer patients treated with entecavir, so as to provide data support for clinical diagnosis and treatment. Based on the survival analysis, the treatment factor x was undertaken as an independent variable to perform linear regression. The regression model took the hazard rate function as the dependent variable to establish an exponential regression equation to construct a PHMM. 136 patients with primary liver cancer receiving interventional chemoembolization combined with the drug (entecavir) were selected as the experimental group, who were in the computer gene expression omnibus (GEO). 87 patients with primary liver cancer who underwent interventional chemoembolization therapy without antiviral treatment were taken as the control group. The PHMM was adopted for comprehensive analysis. In addition, the factors affecting the virological response to antiviral therapy were analyzed using the multiple logistic regression. The results revealed that HBV deoxyribonucleic acid (DNA) negative conversion rate, Hepatitis B e-Antigen (HBeAg) negative conversion rate, and HBeAg serological conversion rate in the experimental group were much higher than those in the control group (P < 0.05). HBV DNA level and proportion of HBsAg <100 IU/mL in the experimental group were much lower than those in the control group (P < 0.05). The virological breakthrough rate and incidence of adverse events at week 24 in the experimental group were greatly lower than those in the control group (P < 0.05). The adverse virological response of patient was positively correlated with HBV DNA load and HBeAg status and negatively correlated with alanine aminotransferase (ALT) level (P < 0.05). Therefore, entecavir can significantly inhibit HBV DNA replication in patients with liver cancer, showing high antiviral effect. High baseline HBV DNA load, positive HBeAg, and low baseline alanine aminotransferase levels were independent risk factors for adverse virology response to entecavir antiviral therapy, which provided a reference for the selection of antiviral drugs for HBV infection.

Highlights

Primary liver cancer is one of the most common malignant tumors in China [1, 2]
136 patients with primary liver cancer who underwent interventional chemoembolization combined with antiviral therapy of entecavir in the computer gene expression omnibus (GEO) data library were selected as the experimental group, and 87 patients with primary hepatocellular carcinoma treated with interventional chemoembolization without antiviral drugs were taken as the control group. is study had been approved by the ethics committee of hospital, and patients and their families had been informed of the study and signed informed consent
Hepatitis B surface antigen is an indicator of Hepatitis B Virus (HBV) infection. e seroconversion of hepatitis B surface antigen shows that the host immune system has an overwhelming advantage over the virus and is used as a sign of recovery from HBV infection

Summary

Introduction

Primary liver cancer is one of the most common malignant tumors in China [1, 2]. China is a major country in the incidence of hepatitis, and the main causes of morbidity and mortality include HBV, HCV, and aflatoxin [3, 4].According to relevant research reports, the proportion of people carrying HBV virus in China is about 10%, and HBV usually acts together with other related factors to lead to the occurrence of cirrhosis, resulting in human hepatocellular carcinoma [5]. Primary liver cancer is one of the most common malignant tumors in China [1, 2]. Journal of Healthcare Engineering often develop to middle to advanced stages when they are discovered. Transcatheter arterial chemoembolization (TACE) is the most common surgical treatment for liver cancer, which has a strong inhibitory and killing effect on tumor. During the period, it will affect the transport of liver blood, cause damage to the normal liver tissues, and greatly reduce the antivirus effect, which will eventually lead to a large number of rapid replications of HBV, resulting in liver failure, hepatic encephalopathy, and other complications [7,8,9]

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